Cryosurgical Ablation (also known as Cryosurgery or Cryo- ablation) is possibly the most promising among so many clinical used ablation treatments. It is carried out by indurating excrescence kerchief with extremely low temperature. Within the tissue of the wart, ice plates begin to develop after tip’s temperature falls below – 40°C. The process involves death of tumour cell causing it to undergo necrosis within excrescence kerchief . Thus, we can assume that progressive failure of microcirculation under cryosurgery implies porous vessel walls of endothelial caste destruction, interstitial edema, platelet aggregation, microthrombi and finally obliteration in vascular bed. The theory was posited that the weak system of these people could be revived during cryosurgery. After cryosurgery, immune system may have been involved because it could destroy those residual excrescence kerchief and metastases not destroyed by cryosurgery alone. This concept was termed “cryo- immunological response”. Procedure for Cryosurgery Depending on the site and size of a lesion, cryotherapy may be carried out through intraoperative routes or percutaneous endoscopic. During procedure tumor an open incision or under image guidance is fitted with 24 mm probes which are cooled using Argon helium freezing and warming systems in two to three cycles of freezing followed by thawing.

The iceball that forms on the tip of the cryoprobe covers a 5-10 mm fringe of normal kerchief, it is still large enough to ablate the entire excrescence. For large excrescences greater than 5 cm in size, either multiple cryoprobes are used or multiple sessions are performed. However, unlike open surgery, this surgical technique is minimally invasive and can be repeated as many times as possible to cure the disease. Advantages Cryosurgery is a single confined medical intervention that may serve independently or be integrated with other traditional ways of treatment such as surgery, chemotherapy and radiation therapy for dealing with complex cases. When combined with excision, it lowers chances of spreading cancer cells while removing them through surgery. If there were any remnants after freezing that didn’t perish especially if the process was done percutaneously, cryosurgery would have still decreased operative bleeding and post operative pain . There are no major side effects which are usually encountered in chemotherapy or radiotherapy; however, cryosurgery can also be applied to tumors located near big vessel that cannot be removed through operation.

Although cryosurgery destroys excrescences that do not respond to standard treatments, it also results in an immunological reaction (cryo-immunological response) that helps fight any residual or metastatic excrescences. Proof exists which shows the rate of cancer recurrence following cryosurgical treatment is lesser in contrast to those treated surgically alone. Numerable patterns of parenchymal neoplasms may be managed by means of cryosurgery, for instance:

*  Liver cancer
*  Lung cancer(non-small cell lung cancer)
*  Kidney cancer
*  Ovarian cancer
*  Pharyngeal cancer
*  Testicular cancer
*  Uterine tumors
*  Vaginal cancer
*  Pancreatic cancer
*  Breast cancer
*  Sarcoma and other benign or malignant lesions of bone
*  Prostate cancer
*  Skin cancer and melanoma
*  Head and neck cancer
*  Tumor of soft tissues

Bonemalignancies ; sarcomas and various benign and malignant bone tumors, prostate cancer, skin cancers including melanoma, headand neck cancers and soft tissue tumors such as fibromatosis . There are other diseases against which cryosurgy has proven effective when used as a treatment.• Retinoblastoma—a rare form of eye cancer that affects children.• Early-stage skin cancer—both basal cell and squamous cell carcinomas.• Actinic keratosis—a precancerous condition of the skin characterized by thick scaly patches on the face, lips, ears, back of hands, forearms or scalp.• (CIN)—abnormal cell changes occur within cervix and later turn into cervical cancer if untreated.