Lung cancer

Lung cancer

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The Role of the Lungs and Issues Related to Lung Cancer

The Role of the Lungs and Issues Related to Lung Cancer

Two lungs, like other organs, assist humans in respiration by taking in oxygen and releasing carbon dioxide. Every breath takes in oxygen which is used by cells in the human body while waste products like carbon dioxide are eliminated through lungs. The lungs serve additional functions including pH balance maintenance, protection against harmful biological and chemical organisms, changing Angiotensin I into Angiotensin II for controlling blood pressure, and a great many other supportive functions. Chronic obstructive pulmonary disease (COPD) is one of many diseases of the lungs which qualify for slowing down one’s life in terms of performing even the most basic activities. Untreated lung cancer, in particular, along with acute progressive respiratory failure, systemic hypoxia, recurrent infections, metastasis to other organs, and hypoxia form some of the worst and most difficult complications.

As with other cancers, lung cancer begins in the lungs, specifically the tissues as well as within the cells that line the passages of the airways. It is generally accepted that the cellular changes, in the form of mutations, lead to uncontrolled division of the cells, birthing malignant tumours. Lung cancer may not be prevalent in every peer group, but it remains among the few cancers which have a global distribution in terms of the most common fatal cancers. It has been noted that the main reasons include late-stage diagnosis, the speed of progression of the disease, and its environmental and lifestyle correlates. Attention is notably lacking as to why disease triggers, such as smoking, lifestyle choices, or environmental toxins, necessitate education and awareness. Public informational campaigns alongside thorough health assessments and well-planned legislation contribute significantly to the correct identification, intervention, and management of health issues.

Associative Groups Of Primary And Secondary Lung Tumours

The classification of “Primary” and “Secondary” types results in a subdivision under Lung Tumours as follows:

Primary Lung Cancer:

This originates directly in the lung tissue. The two main categories include:

New and Squamous Cell Lung Cancer (NSCLC):

Currently, the prevalence of NSCLC as one of the most common forms of cancers in the world is alarming. It accounts for close to eighty percent of all diagnosed cases. Its subtypes generally composed of adenocarcinoma, squamous cell carcinoma and large cell carcinoma.

Small Cell Lung Carcinoma (SCLC):

This is classified as the second type. These aggressively malignant cancers are characterized by rapid dissemination, an initial responsiveness to chemotherapy, and a poor long-term prognosis relative to the former type.

Secondary (Metastatic) Lung Cancer:

Lung cancer can also be caused by metastasis of tumours originating from other organs like the breast, colon, or prostate. Advanced systemic cancers harbouring metastasis are more prone to having lung lesions because such lesions are far more common than primary lung malignancies.

Lung cancer causes and risk factors

Cancerous changes in healthy lung cells often stem from the prolonged exposure to toxic substances, frequent harmful substances, and genetic factors. Other causes and risk factors include:

  • Cigarette Smoking: This remains the most prominent risk factor, accounting for nearly 85% of all lung cancers. It has over 70 known carcinogens, with cigarette smoke containing more than 70 recognized carcinogenic substances.
  • Secondhand smoke: For non-smokers, breathing secondhand smoke also puts them at risk.
  • Radon gas exposure: This gas can build up in poorly ventilated homes.
  • Asbestos-related cancer: Cancer caused by occupational exposure within the construction and shipbuilding fields is linked with asbestos use.
  • Air pollution: Overexposure to industrial pollutant fine particulates may pose severe health consequences over time, with long-term exposure posing considerable danger to public health.
  • Family History and Genetic Predisposition: If combined, elevated familial risk, combined with specific genetic alterations, increases lung cancer risks substantially.
  • Prior radiation therapy: Receiving radiation treatment for other cancers considerably elevates the risk of developing lung cancer.

Symptoms of Lung Cancer

Owing to the absence of symptoms, patients remain asymptomatic during the early stages of the disease, making tumor detection almost impossible.

Common indications are:

  • Coughing up phlegm or a change in patterns of a pre-existing cough.
  • Coughing blood, clinically acknowledged as hemoptysis.
  • Chest pain that worsens with deep inhalation, coughing, or laughing may suggest infection of the lungs.
  • Loss of voice.
  • Weight loss that cannot be accounted for.
  • Tiredness or unusual weakness combined with.
  • SOB (shortness of breath).
  • Recurrent infections such as pneumonia or bronchitis.
  • Pain in the bone could be an indicator of cancer infiltrating its way into its bones.
  • If the cancer advances to the brain, there are observable neurological changes.

Diagnosis of Lung Cancer

Diagnosis involves several steps in testing to confirm cancer and determine how far it has spread:

Taking a Medical History and Physical Exam

Imaging Studies

Conducting a Chest X-ray, CT scan, PET scan, or MRI for lung masses and assessing for metastasis.

Sputum Cytology

Sputum Cytology is an examination method in which mucus from saliva samples is carefully examined to detect cancerous cells.

Biopsy

  • Bronchoscopy: A flexible tube is inserted into the lung to gather tissue samples which a pathologist examines.
  • Needle biopsy: Using a tiny needle with CT or ultrasound guidance to aspirate tissue.
  • Liquid biopsy: Acquiring tissues via blood samples.

Molecular and Genetic Tests

As part of targeted therapy, molecular genetic testing allows physicians to detect specific mutations (EGFR, ALK, or KRAS), enabling targeted drug treatments.

Workup for Staging

Vital for treatment plan selection, including imaging of the bone and brain for metastasis.

Lung Cancer Treatment

Treatment options vary based on health, genetics, type, and stage of disease. They are divided into:

A. Traditional Treatment Options (TTOs)

1. Surgical Procedures

  • Lobectomy: Removal of one lung lobe in early-stage NSCLC.
  • Pneumonectomy: Complete removal of a lung for large or centrally located tumors.
  • Segmentectomy/Wedge Resection: For smaller tumors or patients with limited lung function.

2. Radiation Therapy

  • External Beam Radiation Therapy (EBRT): Uses high-energy beams to target tumors externally.
  • Stereotactic Body Radiotherapy (SBRT): Precision treatment for small tumors.

3. Chemotherapy

Systemic drugs administered via IV or orally to destroy cancer cells. Common medicines include cisplatin, carboplatin, paclitaxel, and docetaxel.

Targeted Therapies

  • EGFR inhibitors: Erlotinib, Afatinib for patients with EGFR mutations.
  • ALK inhibitors: Crizotinib, Alectinib for ALK-positive patients.
  • ROS1 and BRAF targeted agents: For rare mutations.

Targeted Radiation Therapy

  • Brachytherapy: Radioactive seeds near or within tumors for local treatment.
  • Radioembolization: Used for lung tumor metastases to the liver.

Advanced Immunotherapy and Stem Cell Therapies

  • Immunotherapy Drugs: Nivolumab, Pembrolizumab activate T-lymphocytes to attack tumors.
  • CAR-T cell therapy: Clinical trials ongoing for lung and other solid tumors.

Prevention and Lifestyle Management

Strategies focus on controlling exposure to carcinogens:

  • Complete smoking cessation
  • No exposure to secondhand smoke
  • Regular home radon testing
  • Safe handling of asbestos and industrial toxins
  • Antioxidant-rich diet
  • Regular exercise and maintaining proper weight
  • Screening with low-dose CT for high-risk individuals

Prognosis and Survival Statistics

Prognosis depends on general health and intervention methods. According to the American Cancer Society:

  • About 65% five-year survival for localized stage
  • 45% survival for regional spread
  • 35% survival with nearby lymph node involvement
  • 8% survival for distant metastases

Participation in screening programs significantly improves outcomes, especially for high-risk groups like smokers.

Conclusion

Lung cancer remains one of the deadliest cancers. Early detection, risk recognition, prevention, and targeted therapies can improve life expectancy. Education, screening, and innovative treatment approaches provide hope against this devastating disease.

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Explore our range of advanced cancer care procedures designed to provide comprehensive treatment and improve your well-being.

Cancer Icon

Advanced Therapies For Cancer

Innovative and precise cancer treatments combining advanced technology, targeted therapy, and personalized medicine for better recovery outcomes.

Explore More →
Cancer Icon

Treating Specific Cancer

Specialized treatment plans for different cancer types — including liver, lung, breast, and bone cancers — with a focus on patient comfort and long-term wellness.

Explore More →

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